Fenbendazole is a benzimidazole anthelmintic drug with broad antiparasitic activity. It has been used to treat various parasites in humans and other animals since the 1970s. It is absorbed in the small intestine, converted to its active metabolite, oxfendazole, and excreted into the urine. It has also shown promise as an antitumor agent. The results of several studies indicate that fenbendazole may inhibit microtubule-associated tubulin and thereby induce cell cycle arrest or apoptosis in cancer cells. It may also act as a modulator of the RAS-related signaling pathway in cancer cells that have a KRAS mutation. In a phase 1 clinical trial, oxfendazole was administered orally to healthy volunteers to investigate its safety and tolerability levels. It was found to be safe at all tested doses and did not cause significant adverse events in this population. It is currently being evaluated in other clinical trials, including a phase 3 study in patients with advanced pancreatic cancer. The Joe Tippens Cancer Protocol recommends a dose of 222 mg of oral fenbendazole seven days a week. This medication can be taken in the form of granules or a liquid suspension and is best when given with food. Some people may experience diarrhea as a side effect of this protocol, but it is usually tolerable. The Joe Tippens Cancer Protocol has not been studied on large numbers of individuals, but it seems to be a safe and effective treatment for a number of cancers, especially if combined with other natural treatments. This medication is sometimes combined with berberine, another natural supplement that has demonstrated a number of anti-cancer effects. These include the ability to limit the growth of cancer cells by blocking their access to glucose. It can also help to inhibit tumor growth, metastasis, and inflammation. It is important to consult a health care professional before trying this or any other herbal medicine. A recent study published in Oncotarget on July 6 shows that the anti-parasitic drug mebendazole can slow or even stop the spread of pancreatic cancer. Researchers from Johns Hopkins University used two different mouse models to determine that the drug mebendazole prevented the development of pancreatic cancer in these mice, both at early and late stages of the disease. The research team at MD Anderson also discovered that the drugs fenbendazole and albendazole can inhibit the growth of paclitaxel-resistant cancer cells in the lab. In addition, they found that the combination of these drugs has a synergistic effect on the cell’s resistance to paclitaxel. In the laboratory, the drug fenbendazole encapsulated in mPEG-b-PCL micelles was able to inhibit A549 cell colony formation and suppress the proliferation of these cells in hypoxic conditions. These results were further supported by in vivo experiments, where fenbendazole was orally administered to female athymic nu/nu mice that had human lung adenocarcinoma (A549) cells implanted into the abdominal cavity. These mice received fenbendazole every 2 days for 12 days, resulting in a reduction in tumor size and weight.fenbendazole stage 4 cancer